1, 8-cineole (eucalyptol) – 348.8: Naturally Occurring Monoterpene in Aromatic Plants
Not long ago, a research group attempted to identify and report 1, 8-cineole. It is monoterpene which occurs naturally in various aromatic plants. It is one of the most fundamental constituents of the essential oil produced from the leaves of the plant – Hyptis martiusii (EOHM).
It also characterizes the gastroprotective action of the oil. The study was conducted with the aim to investigate or ascertain the mechanisms of action specifically involved in the heating and antiulcer activity of CIN, and for the sake of confirming its correlation with the major gastroprotective effects that belong to EOHM. As per the conclusion of the research study which involves different chemical compounds and processes, 1, 8-cineole (eucalyptol) – 348.8 was found to play an important role as an ulcer heating agent.
The study also indicated the pure involvement of cytoprotective and antioxidant mechanisms with regards to the gastroprotective effect of this compound. The study also showed evidence that this monoterpene is related to the more gastroprotective effect of the Hyptis martiusii essential oil.
Understanding 1, 8-cineole (eucalyptol) – 348.8
A wide range of chemical substances, plant extracts, mixtures of herbs has proved to possess various therapeutic properties in different experimental models related to a peptic ulcer. In fact, the gastroprotective effects of such extracts and compounds, whether in isolation or combined, has been attributed to fundamental three functions including cytoprotective, antisecretory, and antioxidant properties.
1, 8-cineole – 348.8 is also referred to as eucalyptol. It is a monoterpene that is naturally found in various aromatic plants of the Hyptis, Pectis, Eucalyptus, and Croton. There are many previous studies that confirm the research work on the 1, 8-cineole (eucalyptol) – 348.8, conducted to ascertain the number of pharmacological and biological activities including antimicrobial and insecticidal, anti-inflammatory and antiallergic, antitumoral, hepatoprotective and gastroprotective activities.
1, 8-cineole (eucalyptol) – 348.8 is an essential oil that helps in the relaxation of the vascular and bronchial muscle but there is no report of its direct actions on the isolated myocardium. The terpene is present in large quantity in a range of plants that are commonly used to manufacture cosmetics and to increase the percutaneous drugs’ penetration, as the nasal decongestant as well as anti-cough agent, in dentistry and aromatherapy.
1, 8-cineole (eucalyptol) – 348.8 has been utilized to treat sinusitis, bronchitis and chronic rhinitis including the treatment of asthma. All of these actions are more related to the anti-inflammatory action that inhibits the tumor production.
Non Fatal Symptoms of 1, 8-cineole (eucalyptol) – 348.8
There are some non-fatal symptoms observed in children, taking nasal administration of 1, 8-cineole (eucalyptol) – 348.8. Some of the reported effects included irritation of mucous membrane, tachycardia, nausea, dyspnea, muscle weakness, vomiting, coma, and somnolence.
Once; a 3-year-old boy was reported to accidentally ingest 1, 8-cineole (eucalyptol) that caused depression of the entire central nervous system. There are several fatal episodes, reported in humans, resulting from the mouthwash ingestion to accidental exposure, which led to death or multiple organ system failures.
However, since eucalyptol has the potential to relax vascular and bronchial smooth muscles, it might cause a direct action (putative) on the heart muscles.